CAS No. 73069-28-0
Batch:
Purity:99
Chemical Structure
Check the
Praeruptorin B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [8,8-dimethyl-9-[(E)-2-methylbut-2-enoyl]oxy-2-oxo-9,10-dihydropyrano[2,3-f]chromen-10-yl] (E)-2-methylbut-2-enoate | |
|---|---|---|
| CAS Number | 73069-28-0 | |
| Molecular Formula |
C24H26O7 |
|
| Molecular Weight (MW) | 426.46 | |
| InChIKey | PNTWXEIQXBRCPS-FNCQTZNRSA-N |
Praeruptorin B is a natural pyranocoumarin isolated from Peucedanum praeruptorum (Bai-hua Qian-hu) that acts as a lipid-regulating compound. It exerts lipid-lowering effects by suppressing sterol regulatory element-binding proteins (SREBPs), which serve as key transcriptional regulators of lipid biosynthesis. By inhibiting SREBP activation, Praeruptorin B reduces lipogenic gene expression and intracellular lipid accumulation, offering therapeutic potential for hyperlipidemia and related metabolic disorders. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(75.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
32 mg/mL
(75.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.