CAS No. 196868-63-0
Batch:
Purity:99.99
Chemical Structure
Check the
PQ 401
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea | |
|---|---|---|
| CAS Number | 196868-63-0 | |
| Molecular Formula |
C18H16ClN3O2 |
|
| Molecular Weight (MW) | 341.79 | |
| SMILES | CC1=NC2=CC=CC=C2C(=C1)NC(=O)NC3=C(C=CC(=C3)Cl)OC | |
| InChIKey | YBLWOZUPHDKFOT-UHFFFAOYSA-N |
PQ 401 is a diarylurea small-molecule inhibitor of insulin-like growth factor-1 receptor (IGF-1R) that inhibits IGF-1R domain autophosphorylation with an IC50 of <1 μM. By blocking IGF-1R kinase activation, it impairs downstream AKT/mTOR and MAPK signaling pathways. This pathway inhibition suppresses cellular proliferation, induces apoptosis, and attenuates overall tumor cell survival. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(93.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.