CAS No. 931706-15-9
Batch:
Purity:99.86
Chemical Structure
Check the
PPQ-102
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 12,14-dimethyl-9-(5-methylfuran-2-yl)-17-phenyl-1,8,12,14-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-2,4,6,10,16-pentaene-13,15-dione | |
|---|---|---|
| CAS Number | 931706-15-9 | |
| Molecular Formula |
C26H22N4O3 |
|
| Molecular Weight (MW) | 438.48 | |
| SMILES | CC1=CC=C(O1)C2C3=C4C(=C(N3C5=CC=CC=C5N2)C6=CC=CC=C6)C(=O)N(C(=O)N4C)C | |
| InChIKey | MNOOVRNGPIWJDI-UHFFFAOYSA-N |
PPQ-102 is a potent inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, completely inhibiting CFTR chloride current with an IC50 of ~90 nM. Blockade of CFTR-mediated chloride transport suppresses transepithelial fluid secretion and effectively prevents cyst growth and enlargement in preclinical cell and organ culture models of polycystic kidney disease.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(114.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
88 mg/mL
(200.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.