CAS No. 1092364-38-9

Batch: Purity:99.37
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Poziotinib (NOV120101, HM781-36B) Chemical Structure
Chemical Structure
Check the Poziotinib (NOV120101, HM781-36B) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
CAS Number 1092364-38-9
Molecular Formula

C23H21Cl2FN4O3
Molecular Weight (MW) 491.34
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
InChIKey LPFWVDIFUFFKJU-UHFFFAOYSA-N

Ordering Information

Biological Activity

Poziotinib is an irreversible pan-HER inhibitor targeting HER1 (IC50 3.2 nM), HER2 (IC50 5.3 nM), and HER4 (IC50 23.5 nM). By potently inhibiting the kinase activity and autophosphorylation of epidermal growth factor receptors, it disrupts downstream signaling through the AKT/mTOR and MAPK pathways. Consequently, poziotinib suppresses cell proliferation and induces apoptosis along with G1 cell cycle arrest in HER-dependent tumor cells.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (199.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.