CAS No. 2226938-19-6

Batch: Purity:98.43
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Potrasertib Chemical Structure
Chemical Structure
Check the Potrasertib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-(2,6-dichlorophenyl)-12-[3-methyl-4-[(3S,5R)-3,4,5-trimethylpiperazin-1-yl]anilino]-2,5,7,11,13-pentazatricyclo[7.4.0.02,6]trideca-1(13),5,9,11-tetraen-8-one
CAS Number 2226938-19-6
Molecular Formula

C28H30Cl2N8O
Molecular Weight (MW) 565.50
InChIKey BNVDJVMTLDUCGH-HDICACEKSA-N

Biological Activity

Potrasertib is a potent and selective inhibitor of WEE1 kinase. By inhibiting WEE1, it prevents the inhibitory phosphorylation of CDK1, disrupting the G2/M cell cycle checkpoint and accelerating entry into mitosis. This loss of cell cycle regulation leads to accumulation of DNA damage and promotes apoptosis in cancer cells, demonstrating robust antitumor activity across various preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (88.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 7 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hirai H, et al. Mol Cancer Ther. 2009;8(11):2992-3000.

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Note: Technical data last updated: Sep 1, 2026.