CAS No. 78247-49-1

Batch: Purity:98.43
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Potassium guaiacolsulfonate hemihydrate Chemical Structure
Chemical Structure
Check the Potassium guaiacolsulfonate hemihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 78247-49-1
Molecular Formula

C14H16K2O11S2
Molecular Weight (MW) 502.6
SMILES O.[K+].[K+].COC1=C(O)C=CC(=C1)[S]([O-])(=O)=O.COC2=C(O)C=CC(=C2)[S]([O-])(=O)=O

Biological Activity

Potassium guaiacolsulfonate hemihydrate is an expectorant and mucolytic agent. It acts by stimulating respiratory tract secretions, reducing mucus viscosity, and enhancing mucociliary clearance in the airways. These combined actions facilitate the expulsion of phlegm and promote cough productivity. Consequently, it effectively alleviates chest congestion and respiratory discomfort associated with upper respiratory infections, asthma, colds, and hay fever.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 5 mg/mL (9.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water 5 mg/mL
Ethanol 5 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.