CAS No. 1353552-97-2
Batch:
Purity:99.31
Chemical Structure
Check the
Poseltinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-[2-[4-(4-methylpiperazin-1-yl)anilino]furo[3,2-d]pyrimidin-4-yl]oxyphenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1353552-97-2 | |
| Molecular Formula |
C26H26N6O3 |
|
| Molecular Weight (MW) | 470.52 | |
| SMILES | CN1CCN(CC1)C2=CC=C(NC3=NC(=C4OC=CC4=N3)OC5=CC(=CC=C5)NC(=O)C=C)C=C2 | |
| InChIKey | LZMJNVRJMFMYQS-UHFFFAOYSA-N |
Poseltinib (HM71224) is a highly selective inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 1.95 nM. It suppresses the phosphorylation of BTK and its downstream effector PLCγ2 in activated B cells. This target inhibition downregulates inflammatory signaling pathways, leading to reduced production of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β, as well as inhibition of monocyte activation and osteoclastogenesis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
94 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.