CAS No. 1114544-31-8

Batch: Purity:99.89
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Ponatinib hydrochloride Chemical Structure
Chemical Structure
Check the Ponatinib hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride
CAS Number 1114544-31-8
Molecular Formula

C29H27F3N6O.ClH
Molecular Weight (MW) 569.02
InChIKey BWTNNZPNKQIADY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Ponatinib hydrochloride is an orally available multi-targeted tyrosine kinase inhibitor targeting ABL, LYN, PDGFRα, VEGFR2, FGFR1, and SRC. By blocking kinase activity, it suppresses downstream signal transduction through the STAT, AKT, and ERK pathways, ultimately inhibiting proliferation and inducing apoptosis in leukemic and tumor cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (43.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.