CAS No. 42424-50-0
Batch:
Purity:98.58
Chemical Structure
Check the
Polyinosinic-polycytidylic acid sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 42424-50-0 | |
|---|---|---|
| Molecular Formula |
(C10H13N4O8P)x.(C9H14N3O8P)x.xNa |
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| Molecular Weight (MW) | N/A |
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic double-stranded RNA analogue that acts as an agonist of endosomal Toll-like receptor 3 (TLR3) and cytoplasmic melanoma differentiation-associated protein 5 (MDA-5). Activation of these pattern recognition receptors triggers downstream signal transduction pathways, driving the production of type I interferons and proinflammatory cytokines while inducing apoptosis in susceptible cancer cells. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Polyinosinic-polycytidylic acid sodium Solubility in DMSO
- Polyinosinic-polycytidylic acid sodium Stock Solution
- Polyinosinic-polycytidylic acid sodium Storage
- Polyinosinic-polycytidylic acid sodium Stability
- Polyinosinic-polycytidylic acid sodium Molecular Weight
- Polyinosinic-polycytidylic acid sodium Chemical Structure (2D and 3D)
- Polyinosinic-polycytidylic acid sodium SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.