CAS No. 162857-78-5

Batch: Purity:99.91
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Polygalaxanthone III Chemical Structure
Chemical Structure
Check the Polygalaxanthone III product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(2S,3R,4R,5S,6R)-6-[[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]-1,3,6-trihydroxy-7-methoxyxanthen-9-one
CAS Number 162857-78-5
Molecular Formula

C25H28O15
Molecular Weight (MW) 568.48
SMILES COC1=C(C=C2C(=C1)C(=O)C3=C(O2)C=C(C(=C3O)C4C(C(C(C(O4)COC5C(C(CO5)(CO)O)O)O)O)O)O)O
InChIKey LLJUCXMVRPAONX-AYATVRNWSA-N

Ordering Information

Biological Activity

Polygalaxanthone III is a natural xanthone glycoside that acts as a CYP2E1 inhibitor, suppressing chlorzoxazone 6-hydroxylation catalyzed by CYP2E1. By inhibiting CYP2E1 activity, it modulates cytochrome P450-mediated xenobiotic metabolism and reactive oxygen species generation pathways. Downstream blockade of CYP2E1 activity reduces oxidative cellular damage and inflammatory signaling, contributing to its reported tranquilizing, expectorant, and detumescent biological phenotypes. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (175.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.