CAS No. 2565638-16-4
Chemical Structure
Check the
PolQi2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[5-[(5-chloro-2-pyridinyl)methoxy]-1,3,4-thiadiazol-2-yl]-3-(2-methoxyphenyl)pyridine-4-carboxamide | |
|---|---|---|
| CAS Number | 2565638-16-4 | |
| Molecular Formula |
C21H16ClN5O3S |
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| Molecular Weight (MW) | 453.90 | |
| SMILES | O=C(C1=CC=NC=C1C2=C(OC)C=CC=C2)NC3=NN=C(S3)OCC4=NC=C(C=C4)Cl | |
| InChIKey | REZMONWROTVQHG-UHFFFAOYSA-N |
PolQi2 is a DNA polymerase theta (PolΘ) inhibitor that specifically targets the N-terminal helicase domain of PolΘ. By suppressing the alternative end-joining (alt-EJ) repair pathway, this compound enhances gene editing accuracy and integration efficiency across multiple loci and diverse cell lines. Additionally, PolQi2 demonstrates synergistic effects with DNA-PK inhibitors in reducing Cas9-mediated off-target activity, facilitating targeted genomic editing applications. [1]
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Note: Technical data last updated: Sep 1, 2026.