CAS No. 737727-12-7

Batch: Purity:99.68
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PNU-282987 S enantiomer free base Chemical Structure
Chemical Structure
Check the PNU-282987 S enantiomer free base product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 737727-12-7
Molecular Formula

C14H17ClN2O
Molecular Weight (MW) 264.75
SMILES C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl

Biological Activity

PNU-282987 S enantiomer free base is a selective agonist targeting the α7 nicotinic acetylcholine receptor (α7 nAChR). Activation of α7 nAChR modulates cholinergic signaling pathways and regulates synaptic neurotransmission, including GABAergic inhibitory activity in hippocampal circuits. Through this receptor activation, it contributes to neuroprotective cellular mechanisms and the regulation of inflammatory responses in neuronal systems.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 53 mg/mL (200.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 53 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.