CAS No. 123464-89-1
Batch:
Purity:99.82
Chemical Structure
Check the
PNU 282987 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide;hydrochloride | |
|---|---|---|
| CAS Number | 123464-89-1 | |
| Molecular Formula |
C14H18Cl2N2O |
|
| Molecular Weight (MW) | 301.21 | |
| SMILES | C1CN2CCC1C(C2)NC(=O)C3=CC=C(C=C3)Cl.Cl | |
| InChIKey | HSEQUIRZHDYOIX-ZOWNYOTGSA-N |
Biological Activity
PNU 282987 HCl is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with a Ki of 26 nM for the rat receptor. Activation of α7 nAChR modulates cholinergic signal transduction and enhances GABAergic synaptic transmission in hippocampal interneurons, thereby regulating synaptic plasticity, neuronal excitability, and neuroprotective phenotypes in central nervous system models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(152.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 11 mg/mL |
| Ethanol | 4 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.