PMA chemical (Phorbol 12-myristate 13-acetate) Clinical Trials

Size	Price	Qty
5mg	USD 197
25mg	USD 587

Clinical Trials

Multiple clinical trials evaluate interventions across conditions such as apnea of prematurity, respiratory distress syndrome, amyotrophic lateral sclerosis, osteoarthritis, and Crohn disease. Supported by academic medical centers, hospital institutes, and commercial entities—including the University of California, Irvine, Insel Gruppe AG, and Corin—these Phase 2, Phase 4, and non-applicable phase studies demonstrate a broad research scope. The dataset encompasses varied recruitment statuses, including actively recruiting, completed post-approval, terminated, and unknown trials.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06327152	Recruiting	Apnea of Prematurity	University of California Irvine	2024-02-22	Phase 2
NCT02096211	COMPLETED	Non-inflammatory Degenerative Joint Disease; Osteoarthritis; Avascular Necrosis; Post-Traumatic Osteoarthritis of Hip	DePuy Orthopaedics	2014-06-01
NCT05908227	Recruiting	Respiratory Distress Syndrome	Insel Gruppe AG University Hospital Bern	2023-07-01	Not Applicable
NCT06318585	Recruiting	Amyotrophic Lateral Sclerosis\|Motor Neuron Disease	Istituto Auxologico Italiano	2023-04-03	--
NCT06087666	Recruiting	Preterm	Instituto de Investigación Hospital Universitario La Paz	2023-02-01	Not Applicable
NCT05178719	COMPLETED	Osteoporosis	Polyclinic K-center	2016-03-16
NCT04370535	UNKNOWN	Crohn Disease	Ciim Plus, d.o.o.	2018-10-17
NCT03803306	COMPLETED	Essential Hypertension	NMP Medical Research Institute	2018-07-12
NCT02528318	TERMINATED	Respiratory Distress Syndrome	Windtree Therapeutics	2015-08	PHASE2
NCT04607018	COMPLETED	Effects of the Elements	General Hospital Pula	2015-11-17
NCT02074059	COMPLETED	Respiratory Distress Syndrome	Windtree Therapeutics	2014-02	PHASE2
NCT00722007	COMPLETED	Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis	Corin	2008-04-24
NCT00546598	TERMINATED	Non-inflammatory Joint Disease; Osteoarthritis; Avascular Necrosis; Congenital Hip Dysplasia; Post-traumatic Arthritis	DePuy Orthopaedics	2006-01-01	PHASE4

(data from https://clinicaltrials.gov, updated on 2024-05-22)

Check the PMA chemical (Phorbol 12-myristate 13-acetate) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Phorbol 12-myristate 13-acetate operates as a nanomolar activator of protein kinase C, binding to the regulatory domain to drive downstream signaling including sphingosine-1-phosphate induction. This kinase stimulation modulates cellular differentiation, inflammatory responses, and membrane excitability, which underpins research efforts evaluated in clinical trials for conditions such as Crohn disease, respiratory distress syndrome, and osteoarthritis.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).