CAS No. 2446376-25-4
Chemical Structure
Check the
PM534
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4R)-N-[(1R)-1-[4-(cyclopropylmethoxy)-6-oxopyran-2-yl]butyl]-2-[(E)-N-hydroxy-C-methylcarbonimidoyl]-4-methyl-5H-1,3-thiazole-4-carboxamide | |
|---|---|---|
| CAS Number | 2446376-25-4 | |
| Molecular Formula | ||
| InChIKey | FEAXXOSOWZCDTJ-NVUXMUDASA-N |
PM534 is a microtubule-targeting agent that binds to the colchicine-binding site on tubulin and inhibits tubulin assembly. By destabilizing microtubule dynamics, PM534 disrupts mitotic spindle formation, leading to cell cycle arrest and inhibition of cancer cell proliferation. In preclinical models, PM534 significantly suppresses tumor growth in mouse xenograft models of human non-small cell lung cancer, demonstrating potent antitumor activity in vivo.
Note: Technical data last updated: Sep 1, 2026.