CAS No. 1393465-84-3
Batch:
Purity:99.19
Chemical Structure
Check the
PLX7904
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(2-cyclopropylpyrimidin-5-yl)-3-[3-[[ethyl(methyl)sulfamoyl]amino]-2,6-difluorobenzoyl]-1H-pyrrolo[2,3-b]pyridine | |
|---|---|---|
| CAS Number | 1393465-84-3 | |
| Molecular Formula |
C24H22F2N6O3S |
|
| Molecular Weight (MW) | 512.53 | |
| SMILES | CCN(C)S(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CN=C(N=C4)C5CC5)F | |
| InChIKey | DKNZQPXIIHLUHU-UHFFFAOYSA-N |
PLX7904 is a potent and selective paradox-breaker RAF inhibitor. It efficiently inhibits the activation of ERK1/2 in BRAF-mutant melanoma cells without inducing hyperactivation of ERK1/2 in mutant RAS-expressing cells. Through targeted inhibition of downstream MAPK/ERK pathway signaling, PLX7904 suppresses cell proliferation and inhibits tumor growth in BRAF-mutant preclinical cancer models without driving paradoxical pathway activation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.