CAS No. 1627929-55-8
| IUPAC Name | 4-[6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1S)-1-pyridin-2-ylethyl]pyrrolo[3,2-b]pyridin-3-yl]benzoic acid | |
|---|---|---|
| CAS Number | 1627929-55-8 | |
| Molecular Formula |
C26H22N4O3 |
|
| Molecular Weight (MW) | 438.48 | |
| SMILES | CC1=C(C(=NO1)C)C2=CC3=C(C(=CN3C(C)C4=CC=CC=N4)C5=CC=C(C=C5)C(=O)O)N=C2 | |
| InChIKey | AMSUHYUVOVCWTP-INIZCTEOSA-N |
PLX51107 is a novel, potent bromodomain and extra-terminal domain (BET) inhibitor that preferentially targets the first bromodomain over the second bromodomain of BRD2, BRD3, BRD4, and BRDT, while also displaying interaction with CBP and EP300. By competitively blocking BET bromodomain binding to acetylated histones, PLX51107 disrupts chromatin occupancy, suppresses downstream oncogenic gene transcription including MYC expression, and inhibits cancer cell proliferation and survival. [1][2]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(200.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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