CAS No. 1093070-14-4
Batch:
Purity:99.87
Chemical Structure
Check the
PLpro inhibitor
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-acetamido-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide | |
|---|---|---|
| CAS Number | 1093070-14-4 | |
| Molecular Formula |
C22H22N2O2 |
|
| Molecular Weight (MW) | 346.42 | |
| SMILES | CC(NC(=O)C1=C(C)C=CC(=C1)NC(C)=O)C2=CC=CC3=CC=CC=C23 | |
| InChIKey | KGPYBLOBHQLIET-OAHLLOKOSA-N |
PLpro inhibitor is a small-molecule, noncompetitive inhibitor of papain-like protease (PLpro) and deubiquitinase activity. By blocking PLpro activity, it prevents the processing of viral replicase polyproteins and inhibits the dysregulation of host innate immune responses by disrupting cellular deubiquitination and deISGylation pathways. Consequently, this compound suppresses SARS coronavirus replication in host cells without inducing significant cytotoxicity. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 35 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.