CAS No. 94164-88-2

Batch: Purity:99.99
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PKM2-IN-1 (Compound 3k) Chemical Structure
Chemical Structure
Check the PKM2-IN-1 (Compound 3k) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3-methyl-1,4-dioxonaphthalen-2-yl)methyl piperidine-1-carbodithioate
CAS Number 94164-88-2
Molecular Formula

C18H19NO2S2
Molecular Weight (MW) 345.48
SMILES CC1=C(C(=O)C2=CC=CC=C2C1=O)CSC(=S)N3CCCCC3
InChIKey STAFOGVMELKGRI-UHFFFAOYSA-N

Biological Activity

PKM2-IN-1 is a small-molecule inhibitor targeting pyruvate kinase M2 (PKM2) with selectivity over the PKM1 isoform. By inhibiting PKM2 enzymatic activity, the compound modulates cancer cell metabolism and alters glycolytic flux. Blockade of PKM2 disrupts aerobic glycolysis and the Warburg effect, leading to suppressed cell proliferation and reduced tumor cell viability across various cancer cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 6 mg/mL (17.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Christofk HR, et al. Nature. 2008;452(7184):230-3.

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Note: Technical data last updated: Sep 1, 2026.