CAS No. 99534-03-9
Batch:
Purity:99.82
Chemical Structure
Check the
PKI(5-24)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[(E)-(4-hydroxyphenyl)methylideneamino]-3-methyl-7H-[1,2]thiazolo[5,4-d]pyrimidine-4,6-dione | |
|---|---|---|
| CAS Number | 99534-03-9 | |
| Molecular Formula |
C94H148N32O31 |
|
| Molecular Weight (MW) | 2222.38 | |
| InChIKey | ALZDMJPUQGYCAX-MKMNVTDBSA-N |
PKI(5-24) is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) with a Ki of. By competitively binding to the catalytic subunit of PKA, it blocks protein kinase A-mediated phosphorylation within the cAMP/PKA signaling pathway. This target inhibition downregulates downstream intracellular signaling, serving as an effective molecular tool to evaluate cAMP-dependent physiological processes and hormonal signaling regulation. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 50 mg/mL |
| DMSO |
4 mg/mL
(1.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.