CAS No. 374703-78-3

Batch: Purity:99.73
Check CoA
PKG drug G1 Chemical Structure
Chemical Structure
Check the PKG drug G1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 374703-78-3
Molecular Formula

C13H11N3OS
Molecular Weight (MW) 257.31
SMILES CC1=NC2=CC=CC=C2C1=CC3=C(NC(=S)N3)O

Biological Activity

PKG drug G1 is a small-molecule activator of protein kinase G Iα (PKG Iα) that selectively targets the Cys42 residue. By targeting Cys42, it promotes oxidative-like activation of the PKG signaling pathway in vascular smooth muscle cells. This targeted activation drives smooth muscle relaxation, leading to robust vasodilation and effective blood pressure lowering in vivo. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (198.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Burgoyne JR, et al. Science. 2007;317(5843):1393-7.

Jump to

Note: Technical data last updated: Sep 1, 2026.