CAS No. 874146-69-7
Batch:
Purity:99.60
Chemical Structure
Check the
PK11007
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-chloro-2-[(4-fluorophenyl)methylsulfonyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)pyrimidine-4-carboxamide | |
|---|---|---|
| CAS Number | 874146-69-7 | |
| Molecular Formula |
C15H11ClFN5O3S2 |
|
| Molecular Weight (MW) | 427.86 | |
| InChIKey | IVZQUWCWXYFPOQ-UHFFFAOYSA-N |
Biological Activity
PK11007 is a thiol-reactive 2-sulfonylpyrimidine anticancer agent that selectively alkylates surface-exposed cysteines to stabilize p53 without compromising its DNA-binding activity. This stabilization reactivates mutant p53 signaling, up-regulating target genes such as p21 and PUMA. Additionally, PK11007 depletes intracellular glutathione and elevates reactive oxygen species (ROS) levels, inducing endoplasmic reticulum (ER) stress and triggering apoptosis in p53-compromised cancer cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.