CAS No. 38275-34-2
Batch:
Purity:99.63
Chemical Structure
Check the
PK11000
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 38275-34-2 | |
|---|---|---|
| Molecular Formula |
C6H5ClN2O4S |
|
| Molecular Weight (MW) | 236.63 | |
| SMILES | CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl |
PK11000 is a small-molecule covalent stabilizer targeting the DNA-binding domain (DBD) of wild-type and mutant p53 proteins. By targeting cysteine residues within the p53 core domain via covalent modification without disrupting DNA binding, PK11000 stabilizes p53 structure. Reactivation of functional p53 signaling restores tumor suppressor activity, triggering downstream apoptotic pathways to induce cell death in cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(198.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 47 mg/mL |
| Ethanol | 23 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.