CAS No. 85532-75-8
Batch:
Purity:98.70
Chemical Structure
Check the
PK 11195
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 85532-75-8 | |
|---|---|---|
| Molecular Formula |
C21H21ClN2O |
|
| Molecular Weight (MW) | 352.86 |
PK 11195 is a potent antagonist of the translocator protein (TSPO), displaying high affinity in the cerebellum and spinal cord. It also functions as an antagonist of human constitutive androstane receptor (hCAR) and pregnane X receptor (PXR). Target binding modulates mitochondrial function, downstream apoptotic cascades, and cellular inflammatory responses. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(201.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 17 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.