CAS No. 32887-03-9

Batch: Purity:99.04
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Pivmecillinam hydrochloride Chemical Structure
Chemical Structure
Check the Pivmecillinam hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,2-dimethylpropanoyloxymethyl (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride
CAS Number 32887-03-9
Molecular Formula

C21H33N3O5S.HCl
Molecular Weight (MW) 476.03
SMILES CC1(C(N2C(S1)C(C2=O)N=CN3CCCCCC3)C(=O)OCOC(=O)C(C)(C)C)C.Cl
InChIKey UHPXMYLONAGUPC-WKLLBTDKSA-N

Ordering Information

Biological Activity

Pivmecillinam hydrochloride is an orally bioavailable prodrug of mecillinam, a β-lactam antibiotic with selective activity against Gram-negative bacteria. Upon conversion to mecillinam, it specifically targets and inhibits penicillin-binding protein 2 (PBP-2), disrupting bacterial cell wall biosynthesis and peptidoglycan cross-linking. This inhibition impairs cell elongation, inducing spherical cell formation and ultimately leading to bacterial cell lysis. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 95 mg/mL
Ethanol 95 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.