CAS No. 362665-56-3
Batch:
Purity:98.64
Chemical Structure
Check the
Pitolisant
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 362665-56-3 | |
|---|---|---|
| Molecular Formula | ||
| Molecular Weight (MW) | 295850 |
Biological Activity
Pitolisant (BF2.649) is a potent, selective antagonist and inverse agonist of the histamine H3 receptor, exhibiting a Ki value of 0.16 nM and an EC50 of 1.5 nM. By blocking presynaptic H3 autoreceptors, it increases histamine release in the central nervous system, thereby enhancing histaminergic neuronal signaling and promoting vigilance and cognitive function in research models of wakefulness and memory deficits.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(0.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.