CAS No. 2101700-15-4
Batch:
Purity:99.92
Chemical Structure
Check the
Pirtobrutinib (LOXO-305)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide | |
|---|---|---|
| CAS Number | 2101700-15-4 | |
| Molecular Formula |
C22H21F4N5O3 |
|
| Molecular Weight (MW) | 479.43 | |
| SMILES | COC1=CC=C(F)C=C1C(=O)NCC2=CC=C(C=C2)C3=N[N](C(C)C(F)(F)F)C(=C3C(N)=O)N | |
| InChIKey | FWZAWAUZXYCBKZ-NSHDSACASA-N |
Pirtobrutinib (LOXO-305) is a highly selective, non-covalent, next-generation Bruton's tyrosine kinase (BTK) inhibitor. It reversibly binds both wild-type and C481-mutated BTK to effectively disrupt the B-cell receptor (BCR) signaling cascade. By blocking BTK autophosphorylation, pirtobrutinib suppresses downstream signaling through the NF-kB and AKT/mTOR pathways, thereby inhibiting B-cell lymphoma cellular proliferation and survival. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 48 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(200.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 48 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Pirtobrutinib (LOXO-305) Clinical Trials
- Pirtobrutinib (LOXO-305) Solubility in DMSO
- Pirtobrutinib (LOXO-305) Stock Solution
- Pirtobrutinib (LOXO-305) Storage
- Pirtobrutinib (LOXO-305) Stability
- Pirtobrutinib (LOXO-305) Molecular Weight
- Pirtobrutinib (LOXO-305) SMILES
- Pirtobrutinib (LOXO-305) Chemical Structure (2D and 3D)
- Pirtobrutinib (LOXO-305) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.