CAS No. 3605-01-4
Batch:
Purity:99.77
Chemical Structure
Check the
Piribedil
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 3605-01-4 | |
|---|---|---|
| Molecular Formula |
C16H18N4O2 |
|
| Molecular Weight (MW) | 298.34 | |
| SMILES | C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4 |
Piribedil is a selective agonist of dopamine D2 and D3 receptors and an antagonist of α2A- and α2C-adrenergic receptors. By activating D2/D3 receptors and blocking presynaptic α2-adrenergic receptors, it enhances dopaminergic and noradrenergic neurotransmission. These downstream functional actions promote the release of dopamine and acetylcholine in the cerebral cortex, contributing to improved motor functions and cognitive phenotypes.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(197.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
| DMSO |
60 mg/mL
(201.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.