CAS No. 29868-97-1

Batch: Purity:99.98
Check CoA
Pirenzepine dihydrochloride Chemical Structure
Chemical Structure
Check the Pirenzepine dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one;dihydrochloride
CAS Number 29868-97-1
Molecular Formula

C19H21N5O2.2HCl
Molecular Weight (MW) 424.32
SMILES CN1CCN(CC1)CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4.Cl.Cl
InChIKey FFNMBRCFFADNAO-UHFFFAOYSA-N

Biological Activity

Pirenzepine dihydrochloride is a selective M1 muscarinic acetylcholine receptor antagonist. By specifically inhibiting M1 muscarinic receptor activity, it attenuates downstream cholinergic signaling cascades. This selective antagonism effectively suppresses gastric acid secretion at concentrations lower than those required to affect gastrointestinal motility, salivary secretion, cardiovascular activity, ocular function, or central nervous system pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 85 mg/mL
DMSO 2 mg/mL (4.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Hammer R, et al. Nature. 1980;283(5742):90-2.

Jump to

Note: Technical data last updated: Sep 1, 2026.