CAS No. 54-91-1
Batch:
Purity:99.58
Chemical Structure
Check the
Pipobroman
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 54-91-1 | |
|---|---|---|
| Molecular Formula |
C10H16Br2N2O2 |
|
| Molecular Weight (MW) | 356.05 | |
| SMILES | BrCCC(=O)N1CCN(CC1)C(=O)CCBr |
Pipobroman is a piperazine-derived alkylating agent that exhibits potent antiproliferative activity. It functions primarily by cross-linking genomic DNA and interfering with nucleic acid biosynthesis, thereby disrupting DNA replication and transcription pathways. This accumulation of DNA alkylation damage triggers downstream DNA damage response cascades, culminating in cell cycle arrest and the inhibition of cellular proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 71 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.