CAS No. 915967-82-7

Batch: Purity:99.82
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Piperaquine tetraphosphate tetrahydrate Chemical Structure
Chemical Structure
Check the Piperaquine tetraphosphate tetrahydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;phosphoric acid;tetrahydrate
CAS Number 915967-82-7
Molecular Formula

C29H32Cl2N6.4H3O4P.4H2O
Molecular Weight (MW) 999.55
InChIKey AMCQDGFOKTXHSY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Piperaquine tetraphosphate tetrahydrate is a bisquinoline antimalarial agent and an inhibitor of autophagy. It targets heme detoxification mechanisms within the digestive vacuole of Plasmodium falciparum, causing toxic intracellular accumulation of free heme. By inhibiting autophagic pathways and heme polymerization, it disrupts essential nutrient recycling and cellular homeostasis, ultimately impairing parasite viability and suppressing plasmodial survival. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 2 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.