CAS No. 111025-46-8

Batch: Purity:99.83
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Pioglitazone (U-72107) Chemical Structure
Chemical Structure
Check the Pioglitazone (U-72107) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS Number 111025-46-8
Molecular Formula

C19H20N2O3S
Molecular Weight (MW) 356.44
SMILES CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
InChIKey HYAFETHFCAUJAY-UHFFFAOYSA-N

Biological Activity

Pioglitazone (U-72107) is a selective peroxisome proliferator-activated receptor gamma (PPARγ) agonist that also weakly activates PPARα. Upon binding PPARγ, it modulates the transcription of insulin-sensitive genes involved in glucose and lipid metabolism within muscle, adipose tissue, and liver. Downstream, pioglitazone decreases insulin resistance in peripheral tissues, reduces hepatic glucose production, and lowers circulating levels of glucose, insulin, and glycated hemoglobin. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (56.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Lehmann JM, et al. J Biol Chem. 1995;270(22):12953-6.

[2] Sakamoto J, et al. Biochem Biophys Res Commun. 2000;278(3):704-11.

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Note: Technical data last updated: Sep 1, 2026.