CAS No. 29106-36-3

Batch: Purity:99.69
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Pinoresinol dimethyl ether Chemical Structure
Chemical Structure
Check the Pinoresinol dimethyl ether product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S,3aR,6S,6aR)-3,6-bis(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
CAS Number 29106-36-3
Molecular Formula

C22H26O6
Molecular Weight (MW) 386.44
SMILES COC1=C(C=C(C=C1)C2C3COC(C3CO2)C4=CC(=C(C=C4)OC)OC)OC
InChIKey PEUUVVGQIVMSAW-RZTYQLBFSA-N

Biological Activity

Pinoresinol dimethyl ether is a natural lignan compound that acts as an inhibitor of cyclic AMP phosphodiesterase. By inhibiting cyclic AMP phosphodiesterase, it prevents the degradation of intracellular cyclic adenosine monophosphate (cAMP), thereby maintaining elevated cAMP levels and modulating cAMP-dependent signaling cascades. These downstream events influence cellular metabolic processes and signal transduction pathways associated with PDE inhibition.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.