CAS No. 1380288-87-8
Batch:
Purity:99.99
Chemical Structure
Check the
Pinometostat (EPZ5676)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol | |
|---|---|---|
| CAS Number | 1380288-87-8 | |
| Molecular Formula |
C30H42N8O3 |
|
| Molecular Weight (MW) | 562.71 | |
| SMILES | CC(C)N(CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C | |
| InChIKey | LXFOLMYKSYSZQS-XKHGBIBOSA-N |
Pinometostat (EPZ5676) is an S-adenosyl methionine-competitive inhibitor of protein methyltransferase DOT1L (Ki 80 pM) with over 37,000-fold selectivity against other histone methyltransferases. By blocking DOT1L activity, it inhibits histone H3 lysine 79 (H3K79) methylation and suppresses leukemogenic gene expression, resulting in selective inhibition of cell proliferation and induction of apoptosis in MLL-rearranged leukemia cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(177.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(177.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 25 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(177.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(177.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(177.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Pinometostat (EPZ5676) Mechanism of Action: DOT1L Inhibition in Leukemic Blasts Research
- Pinometostat (EPZ5676) Clinical Trials
- Pinometostat (EPZ5676) Working Concentration | Cell Culture | Treatment
- Pinometostat (EPZ5676) Solubility in DMSO
- Pinometostat (EPZ5676) Stock Solution
- Pinometostat (EPZ5676) Storage
- Pinometostat (EPZ5676) Stability
- Pinometostat (EPZ5676) Combination Database
- Pinometostat (EPZ5676) Molecular Weight
- Pinometostat (EPZ5676) SMILES
- Pinometostat (EPZ5676) Chemical Structure (2D and 3D)
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- Pinometostat (EPZ5676) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.