CAS No. 53251-94-8

Batch: Purity:99.84
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Pinaverium bromide Chemical Structure
Chemical Structure
Check the Pinaverium bromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-2-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium bromide
CAS Number 53251-94-8
Molecular Formula

C26H41Br2NO4
Molecular Weight (MW) 591.42
SMILES CC1(C2CCC(C1C2)CCOCC[N+]3(CCOCC3)CC4=CC(=C(C=C4Br)OC)OC)C.[Br-]
InChIKey IKGXLCMLVINENI-UHFFFAOYSA-M

Ordering Information

Biological Activity

Pinaverium bromide is a gastrointestinal-selective calcium channel blocker that targets voltage-dependent calcium channels in smooth muscle cells. By inhibiting L-type calcium channel activation and reducing intracellular calcium influx, it disrupts excitation-contraction coupling in the gastrointestinal tract. This inhibition relaxes gastrointestinal smooth muscle and attenuates hypermotility and spastic contraction, serving as a functional spasmolytic agent in gastrointestinal motility pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (169.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water 16 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.