CAS No. 2062-78-4

Batch: Purity:99.97
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Pimozide Chemical Structure
Chemical Structure
Check the Pimozide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2062-78-4
Molecular Formula

C28H29F2N3O
Molecular Weight (MW) 461.55
SMILES FC1=CC=C(C=C1)C(CCCN2CCC(CC2)N3C(=O)NC4=CC=CC=C34)C5=CC=C(F)C=C5

Ordering Information

Biological Activity

Pimozide is a dopamine receptor antagonist that also acts as a potent inhibitor of STAT3 and STAT5 signaling pathways. By suppressing STAT transcription factor phosphorylation and inhibiting downstream target gene transcription, pimozide disrupts oncogenic signaling in cancer cells. This pathway blockade leads to reduced cell survival, attenuated cell proliferation, and induced apoptotic cell death across multiple leukemia and tumor cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (194.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.