CAS No. 2253123-16-7
Batch:
Purity:99.94
Chemical Structure
Check the
Pimicotinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3,3-dimethyl-N-[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]-2-oxopyrrolidine-1-carboxamide | |
|---|---|---|
| CAS Number | 2253123-16-7 | |
| Molecular Formula |
C22H24N6O3 |
|
| Molecular Weight (MW) | 420.47 | |
| InChIKey | NXFPMDWYDKHFMM-UHFFFAOYSA-N |
Pimicotinib (ABSK021) is an orally bioavailable small-molecule inhibitor targeting colony-stimulating factor 1 receptor (CSF1R). By suppressing CSF1R signaling pathways, it effectively inhibits the proliferation of tumor cells overexpressing CSF1R, triggering cell cycle arrest and inducing apoptosis. In preclinical tumor models, pimicotinib downregulates the proliferative marker Ki67 and upregulates cleaved caspase-3, leading to potent antitumor responses and modulation of macrophage-driven immunosuppression. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.