CAS No. 314-03-4
Batch:
Purity:97.74
Chemical Structure
Check the
Pimethixene
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 314-03-4 | |
|---|---|---|
| Molecular Formula |
C19H19NS |
|
| Molecular Weight (MW) | 293.43 |
Pimethixene is a potent antagonist of the 5-HT2B receptor, functioning additionally as an antihistamine and anticholinergic agent. By blocking serotonin 5-HT2B, histamine H1, and muscarinic acetylcholine receptors, it modulates downstream G-protein-coupled receptor signaling pathways. These multi-target inhibitory actions suppress histamine- and serotonin-mediated cellular responses, leading to attenuated allergic and inflammatory phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 59 mg/mL |
| DMSO |
30 mg/mL
(102.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.