CAS No. 13187-06-9
Batch:
Purity:99.97
Chemical Structure
Check the
Pimethixene maleate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (Z)-but-2-enedioic acid;1-methyl-4-thioxanthen-9-ylidenepiperidine | |
|---|---|---|
| CAS Number | 13187-06-9 | |
| Molecular Formula |
C23H23NO4S |
|
| Molecular Weight (MW) | 409.5 | |
| SMILES | CN1CCC(CC1)=C2C3=CC=CC=C3SC4=CC=CC=C24.OC(=O)\C=C/C(O)=O | |
| InChIKey | IPANUAHQWFDVAG-BTJKTKAUSA-N |
Pimethixene maleate is a potent antagonist of multiple monoamine receptors, exhibiting high binding affinity for histamine H1 receptors, serotonin receptor subtypes (including 5-HT2A and 5-HT2B), and muscarinic M1 and M2 receptors. By blocking these GPCR signaling pathways, it modulates monoaminergic neurotransmission and downstream intracellular calcium mobilization and cAMP signaling, thereby inhibiting mediator-induced smooth muscle contraction, vascular permeability, and central nervous system signaling cascades. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(200.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.