CAS No. 1210416-52-6

Batch: Purity:99.06
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PIM447 (LGH447) Hydrochloride Chemical Structure
Chemical Structure
Check the PIM447 (LGH447) Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]-3-pyridinyl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide;hydrochloride
CAS Number 1210416-52-6
Molecular Formula

C24H23F3N4O.HCl
Molecular Weight (MW) 476.92
SMILES CC1CC(CC(C1)N)C2=C(C=NC=C2)NC(=O)C3=NC(=C(C=C3)F)C4=C(C=CC=C4F)F
InChIKey YLXJAYNSTBYEEU-HWKASLJMSA-N

Ordering Information

Biological Activity

PIM447 (LGH447) Hydrochloride is a novel pan-PIM kinase inhibitor targeting PIM1 (Ki 6 pM), PIM2 (Ki 18 pM), and PIM3 (Ki 9 pM). It displays high selectivity over off-target kinases, including GSK3β, PKN1, and PKCτ. Inhibition of PIM kinase activity disrupts downstream oncogenic signaling pathways, leading to cell cycle arrest and induction of apoptosis in tumor cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (199.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 95 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.