CAS No. 901398-68-3
Batch:
Purity:99.64
Chemical Structure
Check the
PIK-108
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-(1-anilinoethyl)-6-methyl-2-morpholin-4-ylchromen-4-one | |
|---|---|---|
| CAS Number | 901398-68-3 | |
| Molecular Formula |
C22H24N2O3 |
|
| Molecular Weight (MW) | 364.44 | |
| SMILES | CC(NC1=CC=CC=C1)C2=C3OC(=CC(=O)C3=CC(=C2)C)N4CCOCC4 | |
| InChIKey | VRCXIJAYLCUSHC-UHFFFAOYSA-N |
PIK-108 is a non-ATP-competitive, allosteric inhibitor that selectively targets the p110β and p110δ catalytic subunits of phosphoinositide 3-kinase (PI3K). By occupying both catalytic and non-ATP binding pockets in the kinase C-lobe, it induces conformational changes that disrupt lipid binding and class IA PI3K activation. This allosteric modulation suppresses downstream AKT signaling pathways, leading to inhibited cell growth, survival, and proliferation.[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.