CAS No. 64984-31-2

Batch: Purity:99.93
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Pifithrin-μ Chemical Structure
Chemical Structure
Check the Pifithrin-μ product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-phenylethynesulfonamide
CAS Number 64984-31-2
Molecular Formula

C8H7NO2S
Molecular Weight (MW) 181.21
SMILES C1=CC=C(C=C1)C#CS(=O)(=O)N
InChIKey ZZUZYEMRHCMVTB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pifithrin-μ (PFTμ) is a selective p53 inhibitor that inhibits p53 interaction with mitochondria by reducing its affinity for the anti-apoptotic proteins Bcl-xL and Bcl-2. In addition, Pifithrin-μ directly binds and inhibits HSP70 chaperone function. Through these mechanisms, the compound impairs transcription-independent apoptotic signalling, inhibits autophagy, and attenuates radiation-induced cytotoxicity in mammalian cell and tissue models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (198.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 36 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.