CAS No. 60477-34-1
Batch:
Purity:99.47
Chemical Structure
Check the
Pifithrin-β
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole | |
|---|---|---|
| CAS Number | 60477-34-1 | |
| Molecular Formula |
C16H16N2S |
|
| Molecular Weight (MW) | 268.38 | |
| InChIKey | IMUKUMUNZJILCG-UHFFFAOYSA-N |
Pifithrin-β (cyclic pifithrin-α) is a small-molecule inhibitor of the tumor suppressor p53 transcription factor [1, 2]. By suppressing p53-dependent transcriptional activation, it downregulates downstream targets like p21 and counteracts p53-mediated cell cycle arrest and apoptosis [1, 2]. In wild-type p53 tumor cells, cyclic pifithrin-α sensitizes cells to antimicrotubule agent-induced apoptotic cell death [1] and mitigates cell death driven by toxic stressors in neurodegenerative models [2].[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
27 mg/mL
(100.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.