CAS No. 1881233-39-1

Batch: Purity:99.04
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PI4KIIIbeta-IN-10 Chemical Structure
Chemical Structure
Check the PI4KIIIbeta-IN-10 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-[3-[(4-hydroxyphenyl)sulfamoyl]-4-methoxyphenyl]-4-methyl-1,3-thiazol-2-yl]-2,2-dimethylpropanamide
CAS Number 1881233-39-1
Molecular Formula

C22H25N3O5S2
Molecular Weight (MW) 475.58
InChIKey PLUYFBRIGUAKBR-UHFFFAOYSA-N

Biological Activity

PI4KIIIbeta-IN-is a potent small-molecule inhibitor of PI4KIIIβ (IC that exhibits weak activity against off-target lipid kinases including PI3KC2γ, PI4KIIIα, and PI3Kα. Target-specific inhibition of PI4KIIIβ disrupts cellular phosphatidylinositol 4-phosphate synthesis and impairs downstream lipid kinase signaling pathways. Consequently, this compound attenuates intracellular membrane transport processes and suppresses host-factor-dependent viral replication organelle assembly. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 95 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 12 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Rutaganira FU, et al. J Med Chem. 2016;59(5):1830-9.

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Note: Technical data last updated: Sep 1, 2026.