CAS No. 1848242-58-9

Batch: Purity:98.32
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PI3K/mTOR Inhibitor-2 Chemical Structure
Chemical Structure
Check the PI3K/mTOR Inhibitor-2 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[5-(3-chloro-4-oxopyrido[1,2-a]pyrimidin-7-yl)-2-methoxy-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS Number 1848242-58-9
Molecular Formula

C20H13ClF2N4O4S
Molecular Weight (MW) 478.86
SMILES COC1=NC=C(C=C1N[S;v6](=O)(=O)C2=C(F)C=C(F)C=C2)C3=CN4C(=O)C(=CN=C4C=C3)Cl
InChIKey LQTYGHZRBUVRMR-UHFFFAOYSA-N

Biological Activity

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K and mTOR inhibitor belonging to the pyridopyrimidinone class. By simultaneously targeting PI3K and mTOR within the PI3K/AKT/mTOR signaling pathway, this compound effectively suppresses downstream phosphorylation of Akt and p70S6K. Inhibition of these signaling transducers leads to attenuated cell growth and suppresses tumor proliferation in xenograft models, demonstrating robust antitumor activity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 96 mg/mL (200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Yu T, et al. ACS Med Chem Lett. 2018;9(3):256-261.

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Note: Technical data last updated: Sep 1, 2026.