CAS No. 3033069-84-7
Batch:
Purity:99.57
Chemical Structure
Check the
PI3K/AKT-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-(4-methoxyphenyl)-2-methylsulfanyl-6-[(2E)-2-[(3,4,5-trimethoxyphenyl)methylidene]hydrazinyl]pyrimidine-5-carbonitrile | |
|---|---|---|
| CAS Number | 3033069-84-7 | |
| Molecular Formula |
C23H23N5O4S |
|
| Molecular Weight (MW) | 465.53 | |
| InChIKey | WGUUTVSZGSTNKU-DHRITJCHSA-N |
Biological Activity
PI3K/AKT-IN-1 is a dual-acting inhibitor of the PI3K/AKT signaling pathway that targets PI3Kδ, PI3Kγ, and AKT-1. By suppressing activation of the PI3K/AKT cascade, the compound blocks downstream cellular survival mechanisms, leading to S-phase cell cycle arrest and caspase-3-dependent apoptosis. Consequently, it exhibits strong antineoplastic activity and therapeutic potential in models of breast cancer and leukemia. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.