CAS No. 129832-03-7

Batch: Purity:99.1
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Phytic acid dipotassium salt Chemical Structure
Chemical Structure
Check the Phytic acid dipotassium salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name dipotassium;[(2R,3S,5R,6R)-2,3,4,5,6-pentaphosphonooxycyclohexyl] phosphate
CAS Number 129832-03-7
Molecular Formula

C6H16K2O24P6
Molecular Weight (MW) 736.22
SMILES [K+].[K+].O[P](O)(=O)OC1C(O[P](O)(O)=O)C(O[P](O)(O)=O)C(O[P]([O-])([O-])=O)C(O[P](O)(O)=O)C1O[P](O)(O)=O
InChIKey LFTTXUFEVNNTHA-OKBOCSEJSA-L

Biological Activity

Phytic acid dipotassium salt is an endogenous plant-derived metabolite that acts as a potent inhibitor of beta-secretase 1 (BACE1). By blocking BACE1 activity, it suppresses amyloid-beta production and reduces tau hyperphosphorylation within the central nervous system pathway. Consequently, this downregulation mitigates oxidative stress and cellular dysfunction, protecting neuronal cells against amyloid-beta-mediated neurotoxicity in models of Alzheimer's disease. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Anekonda TS, et al. J Alzheimers Dis. 2011;23(1):21-35.

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Note: Technical data last updated: Sep 1, 2026.