CAS No. 805239-56-9
Batch:
Purity:99.81
Chemical Structure
Check the
PHTPP
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol | |
|---|---|---|
| CAS Number | 805239-56-9 | |
| Molecular Formula |
C20H11F6N3O |
|
| Molecular Weight (MW) | 423.31 | |
| SMILES | C1=CC=C(C=C1)C2=NN3C(=CC(=NC3=C2C4=CC=C(C=C4)O)C(F)(F)F)C(F)(F)F | |
| InChIKey | AEZPAUSGTAHLOQ-UHFFFAOYSA-N |
PHTPP is a potent and selective estrogen receptor β (ERβ) antagonist that displays 36-fold binding selectivity for ERβ over ERα. By specifically blocking ligand-induced ERβ activation, PHTPP suppresses estrogen response element (ERE)-dependent transcriptional signaling and modulates downstream signaling networks governing cellular proliferation, survival, and target gene expression in diverse cell types and tissue models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 84 mg/mL |
| DMSO |
50 mg/mL
(118.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.