CAS No. 85-73-4
Batch:
Purity:98
Chemical Structure
Check the
Phthalylsulfathiazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 85-73-4 | |
|---|---|---|
| Molecular Formula |
C17H13N3O5S2 |
|
| Molecular Weight (MW) | 403.43 | |
| SMILES | C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC=CS3)C(=O)O |
Phthalylsulfathiazole is a broad-spectrum sulfonamide antimicrobial agent that acts as an inhibitor of bacterial dihydropteroate synthase (DHPS). By competitively blocking DHPS within the folic acid biosynthetic pathway, it prevents the conversion of para-aminobenzoic acid to dihydropteroate, thereby disrupting bacterial nucleic acid synthesis and cell growth. It displays potent antimicrobial activity against a wide variety of intestinal bacterial pathogens. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(198.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.