CAS No. 2127107-15-5
Batch:
Purity:99.51
Chemical Structure
Check the
PHI-101
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-(carbamoylamino)-5-[2-(3-fluorophenyl)ethynyl]-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide | |
|---|---|---|
| CAS Number | 2127107-15-5 | |
| Molecular Formula |
C19H19FN4O2S |
|
| Molecular Weight (MW) | 386.44 | |
| InChIKey | ULVAGWVTXBTFRN-AWEZNQCLSA-N |
Biological Activity
PHI-is an orally active, potent third-generation inhibitor of FLT3 designed to target FMS-like tyrosine kinase 3 signaling. It overcomes drug resistance mediated by FLT3 internal tandem duplication and tyrosine kinase domain mutations in acute myeloid leukemia. Disruption of FLT3 receptor kinase activity attenuates downstream oncogenic signaling, inhibiting the accumulation and survival of abnormal leukemic hematopoietic precursor cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(183.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.